Uniprot-MCP and PubChem-MCP-Server

These tools are complementary, as one provides access to protein data from UniProt, while the other offers chemical compound data from PubChem, both of which are essential for comprehensive molecular biology research and analysis.

Uniprot-MCP
51
Established
PubChem-MCP-Server
45
Emerging
Maintenance 10/25
Adoption 7/25
Maturity 20/25
Community 14/25
Maintenance 6/25
Adoption 7/25
Maturity 15/25
Community 17/25
Stars: 2
Forks: 3
Downloads: 126
Commits (30d): 0
Language: Python
License: MIT
Stars: 34
Forks: 10
Downloads:
Commits (30d): 0
Language: JavaScript
License:
No risk flags
No Package No Dependents

About Uniprot-MCP

josefdc/Uniprot-MCP

UniProt MCP Server - Access comprehensive protein data via Model Context Protocol. Search, retrieve, and analyze UniProt entries with full-text search, ID mapping, and rich metadata. Supports stdio & HTTP transports for Claude Desktop and custom integrations.

Implements production-grade resilience patterns including exponential backoff retries, concurrent request pooling (configurable to 8 workers), and progress tracking for long-running ID mapping jobs across 200+ database types. Built on FastMCP for stdio and Starlette for HTTP, with Prometheus metrics and structured Pydantic models ensuring type safety for LLM agent integration. Includes VCR-based integration tests, field subsetting to optimize payload sizes, and CORS/health check endpoints for seamless Claude Desktop and custom client deployments.

About PubChem-MCP-Server

Augmented-Nature/PubChem-MCP-Server

A comprehensive Model Context Protocol (MCP) server for accessing the PubChem chemical database. This server provides access to over 110 million chemical compounds with extensive molecular properties, bioassay data, and chemical informatics tools.

This tool helps chemists, biologists, and materials scientists quickly find and analyze chemical compounds from the extensive PubChem database. You can input compound names, formulas, or structures (like SMILES strings) and receive detailed information on molecular properties, biological activities, safety data, and even 3D structures. It's designed for researchers needing rapid access to comprehensive chemical information for drug discovery, material science, or chemical safety assessments.

drug-discovery chemical-informatics materials-science bioactivity-screening compound-profiling

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