Merck/Sapiens
Sapiens is a human antibody language model based on BERT.
Enables humanness scoring, sequence infilling with masked residue prediction, and mutation suggestion for antibody design through separate VH/VL models hosted on HuggingFace. Built on masked language modeling architecture, it generates per-position residue probability scores and sequence embeddings that capture immunological properties learned from natural antibody repertoires. Integrates with HuggingFace transformers ecosystem and provides mutation suggestion capabilities for both framework and CDR regions without requiring mask tokens.
Available on PyPI.
Stars
72
Forks
20
Language
Jupyter Notebook
License
MIT
Category
Last pushed
Jan 22, 2026
Monthly downloads
564
Commits (30d)
0
Dependencies
3
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