ICU Patient Risk Prediction ML Frameworks

Machine learning models for predicting adverse clinical outcomes (mortality, deterioration, sepsis, AKI, intubation need) in ICU patients using EHR data and clinical datasets like MIMIC. Does NOT include general health risk prediction, non-ICU settings, or single-disease diagnosis systems without outcome prediction focus.

There are 66 icu patient risk prediction frameworks tracked. 1 score above 50 (established tier). The highest-rated is rvandewater/YAIB at 60/100 with 93 stars.

Get all 66 projects as JSON

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#	Framework	Score	Tier	Stars	Language
1	rvandewater/YAIB 🧪Yet Another ICU Benchmark: a holistic framework for the standardization of...	60	Established	93	Python
2	YerevaNN/mimic3-benchmarks Python suite to construct benchmark machine learning datasets from the...	44	Emerging	874	Python
3	Mubarraqqq/gnn-challenge This project focuses on predicting maternal-fetal health outcomes,...	41	Emerging	4	Python
4	myADLM/ADLM-2025-Data-Challenge Build an AI Tool for Extracting Information from Laboratory Documentation	40	Emerging	12	—
5	justin13601/ACES [ICLR 2025] ACES: Automatic Cohort Extraction System for Event-Streams	40	Emerging	40	Python
6	cconsta1/SexEst SexEst is an open-source Streamlit web application for predicting biological...	36	Emerging	11	Python
7	AI4HealthUOL/MDS-ICU Repository for the paper 'A Multimodal Deep Learning Framework for...	35	Emerging	5	Python
8	yhzhu99/covid-ehr-benchmarks A Comprehensive Benchmark For COVID-19 Predictive Modeling Using Electronic...	34	Emerging	46	Python
9	futianfan/clinical-trial-outcome-prediction benchmark dataset and Deep learning method (Hierarchical Interaction...	34	Emerging	150	Python
10	Lrebaud/ICARE Individual Coefficient Approximation for Risk Estimation (ICARE) model	33	Emerging	18	Jupyter Notebook
11	MachineLearning-Nerd/Machine-Learning-for-Healthcare-Analytics Machine Learning (ML) has changed the way organizations and individuals use...	32	Emerging	15	HTML
12	vitaliy-ostapchuk93/disease-pattern-miner Disease Pattern Miner is a free, open-source mining framework for...	31	Emerging	12	Java
13	BiomedSciAI/DPM360 Repository for Disease Progression Modeling workbench 360 - An end-to-end...	30	Emerging	19	JavaScript
14	mapo89/continuous-aki-predict Interpretable and continuous AKI prediction in the intensive care	28	Experimental	12	Jupyter Notebook
15	abhisheks008/Predicting-Death-Time-and-Mortality A Machine Learning Approach for Predicting the Death Time and Mortality	27	Experimental	8	Jupyter Notebook
16	hirenhk15/risk-models-for-medical-prognosis An End-to-end Machine Learning System with User Interface for predicting the...	26	Experimental	6	Jupyter Notebook
17	1AyaNabil1/Healthcare-Machine-Learning Explore our open-source repository focused on healthcare machine learning....	26	Experimental	5	Jupyter Notebook
18	SamoraHunter/pat2vec transform patient data to time interval feature vectors	25	Experimental	2	Python
19	CDCgov/machine-learning-influenza-ferret-model Kieran et al. 2024 - Communication Biology - R code for machine learning in...	25	Experimental	—	R
20	javiersgjavi/tabular-mimic-iii repository for easy generation of tabulated dataset from the MIMIC-III database	25	Experimental	5	HTML
21	yhzhu99/pyehr COVID-19 EHR data analysis pipeline	25	Experimental	29	Python
22	javiersgjavi/sepsis-review Baseline to compare the performance of different models with sepsis data...	24	Experimental	7	HTML
23	anondo1969/FedSepsis Repository for the journal article, 'FedSepsis: A Federated Multi-Modal Deep...	24	Experimental	7	Jupyter Notebook
24	vincenzorusso3/mimic-iv-benchmarks FDSML Course Project 2020/21	24	Experimental	15	Python
25	paolomaccallini-hub/SurveyME Reanalysis of the EMEA Pan-European ME Patient Survey by Machine Learning,...	23	Experimental	1	R
26	PERSIMUNE/PAC2022Marandi__DengueML_Plasma_Leakage code repository for a machine learning model for early prediction of plasma...	23	Experimental	2	R
27	anneliset47/ml-pathogenicity.github.io Machine learning classification of genetic variants to predict...	23	Experimental	1	Python
28	bnarasimha21/patient-survival Machine learning model for predicting patient survival outcomes from clinical data	23	Experimental	1	Python
29	iheallab/apricotM This repository contains the official code for the paper "Real-time...	22	Experimental	16	Python
30	Naomiteroh/Seasonal_Flu_Prediction_Analysis Machine learning classification project predicting seasonal flu vaccination...	22	Experimental	—	Jupyter Notebook
31	Joyaji/reproducible-mortality-prediction 🩺 Predict in-hospital mortality using a reproducible deep learning model...	22	Experimental	—	Python
32	paolomaccallini-hub/CompareME Unsupervised clustering of common human diseases based on GWAS and WGS data,...	22	Experimental	—	R
33	regularize-this/sepsis-progression-modeling Bayesian Modeling of Sepsis Progression in the ICU Using MIMIC-IV	22	Experimental	—	Jupyter Notebook
34	AvatarJoshi/copd_project (Ongoing Project) Uses CDC data to map the burden of Chronic Obstructive...	21	Experimental	9	Jupyter Notebook
35	sanjatkanjilal/hospital_onset_infection_analyses Source code for analysis of the impact of environmental and patient-level...	21	Experimental	2	R
36	nicolaDeCristofaro/predictive-models-in-healthcare Data Science & Machine Learning Project applied to Healthcare	20	Experimental	16	Jupyter Notebook
37	i6092467/pediatric-appendicitis-ml Using ML to predict the diagnosis, management, and severity of pediatric appendicitis	20	Experimental	12	R
38	ejw-data/ml-myopia A variety of machine learning techniques used to identify nearsighted patients	18	Experimental	8	Jupyter Notebook
39	Amario1306619051/Patient-Mortality-Prediction-Using-LSTM ## Patient Mortality Prediction Using LSTM 🏥🔍 Welcome to the Patient...	17	Experimental	5	Jupyter Notebook
40	CrezC/RespiForecast ML system predicting flu outbreaks 1-4 weeks ahead with 99.3% accuracy....	15	Experimental	—	Jupyter Notebook
41	nitin2468git/covid19-severity-prediction End-to-end healthcare AI pipeline on MIMIC-IV clinical data — SQL,...	15	Experimental	1	Jupyter Notebook
42	VenkatAmit/aki-risk-prediction BigQuery SQL cohort analysis (MIMIC-III, 40K+ ICU patients) + Python ML for...	14	Experimental	—	Jupyter Notebook
43	KrishnaKJoshi1/icu-mortality-risk-prediction Machine Learning project predicting ICU mortality risk using EHR-derived...	14	Experimental	—	Jupyter Notebook
44	AhmedHassanGondal/Disease-Feature-Analysis Comparing TF-IDF vs One-Hot encoding for disease classification using KNN...	14	Experimental	—	Python
45	Troy-Kieran/Limited-heft-of-weight-based-outcomes-in-predicting-influenza-A-virus-disease-severity-in-ferrets Kieran et al. (under revision) - PLoS Computational Biology	14	Experimental	—	R
46	lcmrhodes/spot-sepsis-cascade Two-stage machine learning cascade and Shiny app for severe febrile illness...	14	Experimental	—	R
47	lcmrhodes/sepsis-spotter-api Research API in R and Plumber for pediatric febrile illness severity...	14	Experimental	—	R
48	ValeriyaKunichik/triage-pro Early clinical risk prediction under epidemic conditions	14	Experimental	—	Jupyter Notebook
49	ahmad-abotrab/patient_survival_prediction In-Hospital Mortality Prediction from Structured Clinical Data	14	Experimental	—	Jupyter Notebook
50	vipulvinit/Healthcare-Symptom-Pattern-Discovery Unsupervised ML pipeline for healthcare symptom pattern discovery using...	14	Experimental	—	Jupyter Notebook
51	Majed-MD-AI/ATLAS-ICU-Deterioration-Prediction Clinical AI project for early ICU deterioration prediction	14	Experimental	—	Jupyter Notebook
52	KODAK-CODER/Flu-Vaccine-Uptake-Prediction Predicting H1N1 and Seasonal Flu vaccine uptake using Random Forest...	14	Experimental	—	Jupyter Notebook
53	VenkatAmit/Healthcare-risk-prediction BigQuery SQL cohort analysis (MIMIC-III, 40K+ ICU patients) + Python ML for...	14	Experimental	—	Jupyter Notebook
54	uh-joan/ct-outcome-predictor Clinical trial outcome predictor — 0.926 AUC-ROC on held-out Phase 2/3...	14	Experimental	—	Python
55	ctkqiang/Influenza-ML 本项目开发了一个基于机器学习的禽流感病毒(H5N1)预测系统，旨在通过分析历史数据和实时社交媒体信息，对禽流感疫情进行预测和风险评估。该系统采用决策树算法...	13	Experimental	6	Python
56	GitData-GA/h5n1 The study focuses on modeling and predicting H5N1 bird flu outbreaks in the...	12	Experimental	—	CSS
57	marcusosterberg/triage-at-home ML-testprojekt för att använda NLP-teknik för att klassificera, ge...	12	Experimental	3	Jupyter Notebook
58	daehan-lim/associative-classifier-mortality-prediction An interpretable associative classifier for predicting patient mortality...	12	Experimental	4	Jupyter Notebook
59	Koonarm/Early_SEPSIS_ML Machine learning models for early sepsis prediction using EMR data	12	Experimental	1	—
60	godseritesh/OptiHeart_Retinal_Insight_to_Cardiac_Health This repository contains an advanced machine learning solution for heart...	11	Experimental	2	Jupyter Notebook
61	TamimSaykat/icu-intubation-need-predictor End-to-end ICU intubation risk prediction system on MIMIC-IV!	11	Experimental	—	—
62	Kataki-Niv/RiskLens-ad Interpretable machine learning system for Alzheimer’s risk stratification...	11	Experimental	—	—
63	madhusai85/Heart-Disease-Prediction An advanced cardiovascular risk prediction system using Explainable AI...	11	Experimental	—	Jupyter Notebook
64	CareNX-Innovations-Pvt-Ltd/fetosense_auto Fetosense Auto brings automation and intelligence to portable fetal...	11	Experimental	—	Jupyter Notebook
65	UltiPro/DeathRiskAI DeathRiskAI created by Patryk 'UltiPro' Wójtowicz using Scikit Learn and Tensorflow.	11	Experimental	—	Jupyter Notebook
66	WFLiu0327/Awesome-for-AI-in-Cardiovascular A detailed awesome for Artificial Intelligence in Cardiovascular	10	Experimental	1	—

Comparisons in this category

covid-ehr-benchmarks and pyehr (34 vs 25)